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Home BioTechnology

Human stromal corneal lenticule implantation for refractory full-thickness macular holes: surgical method and preliminary outcomes

Future News 24 by Future News 24
July 11, 2026
in BioTechnology
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Human stromal corneal lenticule implantation for refractory full-thickness macular holes: surgical method and preliminary outcomes
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Anatomical closure was achieved in all circumstances at 1-month follow-up. (Fig. 1) Intraoperative and postoperative OCT confirmed secure lenticule integration, constantly exhibiting a hyperreflective subfoveal band and full 360° protection beneath the retinal edges. (Fig. 2) No intraoperative or early postoperative issues had been noticed. These findings counsel early structural integration with secure retinal structure at short-term follow-up.

Fig. 1: Consultant case.
Fig. 1: Representative case.

Preoperative and postoperative OCT imaging demonstrating profitable hSCL positioning and macular gap closure.

Fig. 2: Intraoperative view.
Fig. 2: Intraoperative view.

Intraoperative OCT confirming appropriate submacular positioning of the hSCL. The white sq. signifies a magnified view of the foveal area and the white arrow highlights the lenticule throughout the macular gap.

These outcomes help the feasibility of hSCL implantation in rFTMH. Whereas earlier studies have explored heterogeneous purposes of lenticule implantation, this strategy focuses on the standardisation of a refined surgical method particularly for refractory macular holes. In contrast with amniotic membrane–based mostly approaches, stromal lenticules might supply a extra structurally secure scaffold derived from native ocular stroma, probably favouring extra constant tissue integration.

This strategy introduces a biologically derived stromal scaffold, probably increasing present surgical methods past purely mechanical closure. Future developments might embody the usage of stromal lenticules derived from residing donors inside devoted tissue banking platforms, enabling standardised and probably bioengineered purposes.

Supplemental materials is accessible at Eye’s web site.



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Tags: cornealfullthicknessholesHumanimplantationlenticulemacularoutcomespreliminaryrefractorystromalsurgicaltechnique
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