{"id":4412,"date":"2026-08-28T00:00:00","date_gmt":"2026-08-28T00:00:00","guid":{"rendered":"https:\/\/futurenews24.com\/index.php\/2026\/08\/28\/d44224-026-00013-5\/"},"modified":"2026-08-29T18:59:18","modified_gmt":"2026-08-29T18:59:18","slug":"d44224-026-00013-5","status":"publish","type":"post","link":"https:\/\/futurenews24.com\/index.php\/2026\/08\/28\/d44224-026-00013-5\/","title":{"rendered":"What brief reads miss: unlocking cryptic most cancers variants with nanopore sequencing"},"content":{"rendered":"


\n<\/p>\n

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REGISTER NOW<\/p>\n

\"Oxford<\/figure>\n

Figuring out whether or not a number of cancer-associated variants happen on the identical chromosome (cis) or reverse chromosomes (trans) stays a substantial problem with typical short-read sequencing. Nonetheless, this distinction can have necessary implications for understanding illness biology and assessing pathogenicity. Lengthy-read nanopore sequencing permits direct haplotype phasing whereas concurrently detecting structural variation, DNA methylation and complicated genomic rearrangements in a single assay, offering a extra complete view of genomic alterations.<\/p>\n

This webcast will reveal how long-read sequencing know-how from Oxford Nanopore is being utilized to real-world tumour samples, together with prostate, breast, ovarian and different uncommon cancers, to resolve cryptic genomic occasions that would not be absolutely characterised utilizing typical sequencing approaches. The session will even reveal how haplotype phasing, direct methylation detection and structural variant evaluation are offering deeper organic insights into tumour-suppressor inactivation, in addition to revealing doubtlessly clinically related compound oncogenic alleles and bettering confidence within the interpretation of each somatic and germline variants.<\/p>\n

Find out how:<\/p>\n

\u2022 Lengthy-read nanopore sequencing permits haplotype phasing, bettering the interpretation of complicated most cancers genomes<\/p>\n

\u2022 Combining a number of approaches in a single experiment can present a extra full understanding of genomic alterations in tumours<\/p>\n

\u2022 Adaptive sequencing can enhance analysis workflow effectivity and cut back prices<\/p>\n

Unable to affix the stay occasion? Watch on demand. Register now to make sure that you obtain data on find out how to achieve entry after the stay occasion.<\/p>\n

This webcast has been produced by Oxford Nanopore Applied sciences, who retains sole accountability for content material. About this content material.<\/p>\n

Oxford Nanopore Applied sciences merchandise are RUO. Merchandise labelled\/branded as Oxford Nanopore Diagnostics could also be RUO or could also be regulated as in-vitro diagnostic gadgets in some jurisdictions, please verify particular person product labelling. Oxford Nanopore Applied sciences current the supplies of third events throughout the consumer group acknowledging that these supplies belong to and are the true statements and representations of these third events. Oxford Nanopore Applied sciences make no endorsements of the supplies proven and the statements made.<\/p>\n

Audio system<\/h2>\n

Dan Robinson, Affiliate Analysis Professor, Michigan Heart for Translational Pathology, College of Michigan<\/p>\n

\"Dan<\/figure>\n

Dr Dan Robinson is the Director of the MI-ONCOSEQ medical sequencing laboratory. His predominant curiosity is advancing precision oncology and most cancers genomics by way of integrative sequencing and analyses of DNA and RNA utilizing superior applied sciences.<\/p>\n

Anantha Poluri, Affiliate Director, Regional Advertising and marketing, Oxford Nanopore Applied sciences<\/p>\n

\"Anantha<\/figure>\n

Anantha Poluri is Affiliate Director of Regional Advertising and marketing at Oxford Nanopore Applied sciences. She brings greater than 24 years of expertise throughout genomics and life sciences, spanning R&D, gross sales, product administration and product advertising. Anantha holds a PhD in Molecular Virology and Microbiology from Baylor School of Drugs, the place her analysis targeted on advancing HIV-based lentiviral vector design for gene remedy.<\/p>\n

Moderator<\/h2>\n

Alison Halliday, Freelance Science Author<\/p>\n

\"Alison<\/figure>\n

Alison Halliday, PhD, is a contract science author, specializing in life sciences, biomedicine and well being tales. Following her doctorate on the College of Newcastle and postdoctoral analysis into human molecular genetics at College School London, she moved into science communications. With greater than 25 years of expertise spanning academia, business and non-profit sectors \u2013 together with a decade at Most cancers Analysis UK \u2013 she has collaborated with Nature Analysis Customized Media since 2019.<\/p>\n<\/p><\/div>\n


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Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

REGISTER NOW Figuring out whether or not a number of cancer-associated variants happen on the identical chromosome (cis) or reverse chromosomes (trans) stays a substantial problem with typical short-read sequencing. Nonetheless, this distinction can have necessary implications for understanding illness biology and assessing pathogenicity. Lengthy-read nanopore sequencing permits direct haplotype phasing whereas concurrently detecting structural […]<\/p>\n","protected":false},"author":1,"featured_media":4414,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/media.nature.com\/lw1200\/magazine-assets\/d44224-026-00013-5\/d44224-026-00013-5_53180748.png","fifu_image_alt":"","jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"jnews_override_bookmark_settings":[],"jnews_social_meta":[],"jnews_override_counter":[],"footnotes":""},"categories":[10],"tags":[303,4605,4607,4604,4608,4603,956,4606],"class_list":["post-4412","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotechnology","tag-cancer","tag-cryptic","tag-nanopore","tag-reads","tag-sequencing","tag-short","tag-unlocking","tag-variants"],"yoast_head":"\nWhat brief reads miss: unlocking cryptic most cancers variants with nanopore sequencing - 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