{"id":2459,"date":"2026-07-17T01:52:00","date_gmt":"2026-07-17T01:52:00","guid":{"rendered":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/"},"modified":"2026-07-17T07:59:07","modified_gmt":"2026-07-17T07:59:07","slug":"modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice","status":"publish","type":"post","link":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/","title":{"rendered":"Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<div class=\"td-post-featured-image\">\n<figure><img decoding=\"async\" width=\"696\" height=\"479\" class=\"entry-thumb td-modal-image\" src=\"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927-696x479.jpg\" srcset=\"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927-696x479.jpg 696w, https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927-1392x958.jpg 1392w\" sizes=\"(-webkit-min-device-pixel-ratio: 2) 1392px, (min-resolution: 192dpi) 1392px, 696px\" alt=\"Antibody\u2013drug conjugates\" title=\"Antibody drug conjugate, illustration\"\/><figcaption class=\"wp-caption-text\">Credit score: THOM LEACH \/ SCIENCE PHOTO LIBRARY \/ Getty Photos<\/figcaption><\/figure>\n<\/div>\n<p>Most cancers medicine that may discover and kill tumor cells with molecular precision have reshaped oncology\u2014however their energy fades when tumors evolve, diversify, or just cease presenting the appropriate molecular targets. Now, researchers at Washington College (WashU) College of Drugs in St. Louis have unveiled a modular \u201cclick on\u2011to\u2011assemble\u201d technique that supercharges these therapies contained in the physique, permitting them to hit a number of tumor targets without delay and reverse drug resistance in mice.<\/p>\n<p><span style=\"white-space: pre-wrap;\">The examine, revealed in Nature, is titled \u201cModular in vivo antibody\u2013ADC click on to reverse drug resistance in tumors,\u201d and introduces a bioorthogonal ligation technique that types a twin\u2011concentrating on antibody\u2013drug conjugate (ADC) with improved tumor uptake and therapeutic efficacy. In pancreatic, gastric, and breast most cancers fashions, the method slowed or halted tumor development\u2014even in tumors with <span style=\"font-weight: normal;\">low, ultralow, or heterogeneous HER2 expression<\/span>, the place typical HER2\u2011directed ADCs usually fail.<\/span><\/p>\n<p>\u201cWe\u2019ve proven that when two most cancers\u2011concentrating on antibodies bind collectively contained in the physique, they accumulate on the tumor extra successfully and enhance remedy response,\u201d stated senior creator <span style=\"font-weight: normal;\">Patr\u00edcia M. Ribeiro Pereira, PhD<\/span>, assistant professor of radiology at WashU Drugs\u2019s Mallinckrodt Institute of Radiology. \u201cThere may be a variety of pleasure right here as a result of we now have proven that it isn\u2019t essential to create an entire new drug platform for every therapeutic goal. We are able to repurpose antibodies that exist already to enhance remedies.\u201d<\/p>\n<p><span style=\"white-space: pre-wrap;\">The workforce\u2019s technique\u2014referred to as <span style=\"font-weight: normal;\">antibody\u2013ADC click on<\/span>\u2014depends on the fast ligation between trans\u2011cyclooctene (TCO) and tetrazine moieties. Within the examine, one antibody (similar to panitumumab, concentrating on EGFR) was modified with TCO, whereas a second antibody or ADC (similar to trastuzumab\u2011deruxtecan, T\u2011DXd) carried tetrazine. When administered sequentially, the 2 elements \u201cclicked\u201d collectively, forming a better\u2011order advanced that internalized extra effectively and delivered extra cytotoxic payload.<\/span><\/p>\n<p><span style=\"white-space: pre-wrap;\">The paper described the issue bluntly: \u201cADC efficacy stays constrained by its dependence on a single goal antigen, which limits tumor concentrating on and promotes resistance in heterogeneous tumors with variable and low antigen expression.\u201d The press technique, the authors wrote, \u201coffers a modular and translatable method for enhanced focused drug supply in heterogeneous tumors.\u201d<\/span><\/p>\n<p><span style=\"white-space: pre-wrap;\">In mice bearing tumors with mismatched HER2 and EGFR expression, the clicked ADCs collected at ranges as much as <span style=\"font-weight: normal;\">3.2\u2011fold increased<\/span> than commonplace ADCs. <\/span><\/p>\n<p><span style=\"white-space: pre-wrap;\">The modularity is the purpose. \u201cThe method is versatile sufficient to be tailored to new most cancers targets as we be taught extra about what drives remedy resistance,\u201d Ribeiro Pereira added. <\/span><\/p>\n<p><span style=\"white-space: pre-wrap;\">Subsequent steps embody additional improvement and optimization of the click-enabled ADC platform previous to future medical translation, together with increasing the platform to notoriously onerous\u2011to\u2011deal with cancers. \u201cWe\u2019re making an attempt to optimize this instrument to assist antibodies attain tumors which can be usually very tough to deal with, similar to mind tumors,\u201d Ribeiro Pereira stated.<\/span><\/p>\n<\/p><\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.genengnews.com\/topics\/cancer\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit score: THOM LEACH \/ SCIENCE PHOTO LIBRARY \/ Getty Photos Most cancers medicine that may discover and kill tumor cells with molecular precision have reshaped oncology\u2014however their energy fades when tumors evolve, diversify, or just cease presenting the appropriate molecular targets. Now, researchers at Washington College (WashU) College of Drugs in St. Louis have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2461,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg","fifu_image_alt":"","jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"jnews_override_bookmark_settings":[],"jnews_social_meta":[],"jnews_override_counter":[],"footnotes":""},"categories":[10],"tags":[2953,657,2954,497,2958,2952,2955,2957,2956],"class_list":["post-2459","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotechnology","tag-antibodyadc","tag-chemistry","tag-click","tag-drug","tag-mice","tag-modular","tag-overcomes","tag-resistance","tag-tumor"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice - Future News 24<\/title>\n<meta name=\"description\" content=\"The team\u2019s strategy\u2014called antibody\u2013ADC click\u2014relies on the rapid ligation between trans\u2011cyclooctene (TCO) and tetrazine moieties.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice - Future News 24\" \/>\n<meta property=\"og:description\" content=\"The team\u2019s strategy\u2014called antibody\u2013ADC click\u2014relies on the rapid ligation between trans\u2011cyclooctene (TCO) and tetrazine moieties.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/\" \/>\n<meta property=\"og:site_name\" content=\"Future News 24\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-17T01:52:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-17T07:59:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg\" \/>\n<meta name=\"author\" content=\"Future News 24\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Future News 24\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/\"},\"author\":{\"name\":\"Future News 24\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#\\\/schema\\\/person\\\/cecad1bde21cfc357cf70128144d6c83\"},\"headline\":\"Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice\",\"datePublished\":\"2026-07-17T01:52:00+00:00\",\"dateModified\":\"2026-07-17T07:59:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/\"},\"wordCount\":515,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.genengnews.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg\",\"keywords\":[\"AntibodyADC\",\"Chemistry\",\"Click\",\"drug\",\"Mice\",\"Modular\",\"Overcomes\",\"Resistance\",\"Tumor\"],\"articleSection\":[\"BioTechnology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/\",\"url\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/\",\"name\":\"Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice - Future News 24\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.genengnews.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg\",\"datePublished\":\"2026-07-17T01:52:00+00:00\",\"dateModified\":\"2026-07-17T07:59:07+00:00\",\"description\":\"The team\u2019s strategy\u2014called antibody\u2013ADC click\u2014relies on the rapid ligation between trans\u2011cyclooctene (TCO) and tetrazine moieties.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.genengnews.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg\",\"contentUrl\":\"https:\\\/\\\/www.genengnews.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/07\\\/17\\\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/futurenews24.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#website\",\"url\":\"https:\\\/\\\/futurenews24.com\\\/\",\"name\":\"Future News 24\",\"description\":\"The Smart Hub for AI and Next-Gen Innovation\",\"publisher\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/futurenews24.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#organization\",\"name\":\"Future News 24\",\"url\":\"https:\\\/\\\/futurenews24.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/futurenews24.com\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/fn24-favicon.png\",\"contentUrl\":\"https:\\\/\\\/futurenews24.com\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/fn24-favicon.png\",\"width\":250,\"height\":250,\"caption\":\"Future News 24\"},\"image\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#\\\/schema\\\/person\\\/cecad1bde21cfc357cf70128144d6c83\",\"name\":\"Future News 24\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g\",\"caption\":\"Future News 24\"},\"sameAs\":[\"https:\\\/\\\/futurenews24.com\"],\"url\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/author\\\/mridulpahuja20\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice - Future News 24","description":"The team\u2019s strategy\u2014called antibody\u2013ADC click\u2014relies on the rapid ligation between trans\u2011cyclooctene (TCO) and tetrazine moieties.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/","og_locale":"en_US","og_type":"article","og_title":"Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice - Future News 24","og_description":"The team\u2019s strategy\u2014called antibody\u2013ADC click\u2014relies on the rapid ligation between trans\u2011cyclooctene (TCO) and tetrazine moieties.","og_url":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/","og_site_name":"Future News 24","article_published_time":"2026-07-17T01:52:00+00:00","article_modified_time":"2026-07-17T07:59:07+00:00","og_image":[{"url":"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg","type":"","width":"","height":""}],"author":"Future News 24","twitter_card":"summary_large_image","twitter_image":"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg","twitter_misc":{"Written by":"Future News 24","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/#article","isPartOf":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/"},"author":{"name":"Future News 24","@id":"https:\/\/futurenews24.com\/#\/schema\/person\/cecad1bde21cfc357cf70128144d6c83"},"headline":"Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice","datePublished":"2026-07-17T01:52:00+00:00","dateModified":"2026-07-17T07:59:07+00:00","mainEntityOfPage":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/"},"wordCount":515,"commentCount":0,"publisher":{"@id":"https:\/\/futurenews24.com\/#organization"},"image":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/#primaryimage"},"thumbnailUrl":"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg","keywords":["AntibodyADC","Chemistry","Click","drug","Mice","Modular","Overcomes","Resistance","Tumor"],"articleSection":["BioTechnology"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/","url":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/","name":"Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice - Future News 24","isPartOf":{"@id":"https:\/\/futurenews24.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/#primaryimage"},"image":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/#primaryimage"},"thumbnailUrl":"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg","datePublished":"2026-07-17T01:52:00+00:00","dateModified":"2026-07-17T07:59:07+00:00","description":"The team\u2019s strategy\u2014called antibody\u2013ADC click\u2014relies on the rapid ligation between trans\u2011cyclooctene (TCO) and tetrazine moieties.","breadcrumb":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/#primaryimage","url":"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg","contentUrl":"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/03\/May_ADC_GettyImages_JL_2147604791_AntibodyDrugConjugate-e1775154897927.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/futurenews24.com\/index.php\/2026\/07\/17\/modular-antibody-adc-click-chemistry-overcomes-tumor-drug-resistance-in-mice\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/futurenews24.com\/"},{"@type":"ListItem","position":2,"name":"Modular Antibody\u2013ADC Click on Chemistry Overcomes Tumor Drug Resistance in Mice"}]},{"@type":"WebSite","@id":"https:\/\/futurenews24.com\/#website","url":"https:\/\/futurenews24.com\/","name":"Future News 24","description":"The Smart Hub for AI and Next-Gen Innovation","publisher":{"@id":"https:\/\/futurenews24.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/futurenews24.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/futurenews24.com\/#organization","name":"Future News 24","url":"https:\/\/futurenews24.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/futurenews24.com\/#\/schema\/logo\/image\/","url":"https:\/\/futurenews24.com\/wp-content\/uploads\/2026\/06\/fn24-favicon.png","contentUrl":"https:\/\/futurenews24.com\/wp-content\/uploads\/2026\/06\/fn24-favicon.png","width":250,"height":250,"caption":"Future News 24"},"image":{"@id":"https:\/\/futurenews24.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/futurenews24.com\/#\/schema\/person\/cecad1bde21cfc357cf70128144d6c83","name":"Future News 24","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g","caption":"Future News 24"},"sameAs":["https:\/\/futurenews24.com"],"url":"https:\/\/futurenews24.com\/index.php\/author\/mridulpahuja20\/"}]}},"_links":{"self":[{"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/posts\/2459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/comments?post=2459"}],"version-history":[{"count":1,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/posts\/2459\/revisions"}],"predecessor-version":[{"id":2460,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/posts\/2459\/revisions\/2460"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/media\/2461"}],"wp:attachment":[{"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/media?parent=2459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/categories?post=2459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/tags?post=2459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}