{"id":1362,"date":"2026-06-23T00:00:00","date_gmt":"2026-06-23T00:00:00","guid":{"rendered":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/"},"modified":"2026-06-23T04:59:33","modified_gmt":"2026-06-23T04:59:33","slug":"s41538-026-00958-6","status":"publish","type":"post","link":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/","title":{"rendered":"Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div id=\"Abs1-content\">\n<p>World meals safety calls for sustainable options to the standard feed ingredient wheat. Nutrient-dense diploid potatoes (HQP) characterize candidates because of their enriched phytochemical profiles, together with excessive ranges of vitamin C and lutein. Nonetheless, their dietary utilization is constrained by endogenous anti-nutritional components (ANFs), primarily solanine and trypsin inhibitors. Utilizing a zebrafish mannequin, we display that these ANFs set off intestinal dysbiosis and an oxidative-inflammatory response. Mechanistically, this antagonistic intestine atmosphere suppresses the mTOR pathway, as evidenced by lowered phosphorylation of S6K1 and 4E-BP1, finally resulting in progress despair. To handle this toxicological barrier, we built-in genetic choice (diploid HQP) with thermal processing (steam-cooking). Quantitative evaluation revealed that whereas thermal processing successfully lowered ANF concentrations to physiologically protected ranges, the HQP matrix retained considerably greater residual concentrations of vitamin C, lutein, and zeaxanthin in comparison with standard tetraploid (C88) and wheat-based diets. Mechanistically, protein-level proof confirmed that this processed HQP formulation promoted the overall NRF2 and suppressed NF-\u03baB P65 accumulation. This metabolic shift attenuated irritation, reactivated mTOR signaling, and subsequently enhanced progress efficiency and digestive capability. Our findings set up a mechanistic framework demonstrating how built-in genomic design and processing methods facilitate the purposeful utilization of high-phytochemical crops in sustainable meals techniques.<\/p>\n<div class=\"c-article-section__figure\" data-test=\"figure\" data-container-section=\"figure\">\n<figure>\n<div class=\"c-article-section__figure-content\">\n<div class=\"c-article-section__figure-item\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/lw685\/springer-static\/image\/art%3A10.1038%2Fs41538-026-00958-6\/MediaObjects\/41538_2026_958_Figa_HTML.png\" alt=\"\" loading=\"lazy\" width=\"685\" height=\"382\"\/><\/div>\n<\/div>\n<\/figure>\n<\/div>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.nature.com\/articles\/s41538-026-00958-6\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>World meals safety calls for sustainable options to the standard feed ingredient wheat. Nutrient-dense diploid potatoes (HQP) characterize candidates because of their enriched phytochemical profiles, together with excessive ranges of vitamin C and lutein. Nonetheless, their dietary utilization is constrained by endogenous anti-nutritional components (ANFs), primarily solanine and trypsin inhibitors. Utilizing a zebrafish mannequin, we [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1364,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41538-026-00958-6\/MediaObjects\/41538_2026_958_Figa_HTML.png","fifu_image_alt":"","jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"jnews_override_bookmark_settings":[],"jnews_social_meta":[],"jnews_override_counter":[],"footnotes":""},"categories":[10],"tags":[1803,1804,824,1808,1807,1805,1800,1802,1806,1809,1069,1799,1801],"class_list":["post-1362","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotechnology","tag-antinutritional","tag-constraints","tag-design","tag-diploid","tag-efficacy","tag-enhance","tag-genomic","tag-mitigate","tag-nutritional","tag-potatoes","tag-processing","tag-synergistic","tag-thermal"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes - Future News 24<\/title>\n<meta name=\"description\" content=\"Global food security demands sustainable alternatives to the conventional feed ingredient wheat. Nutrient-dense diploid potatoes (HQP) represent candidates due to their enriched phytochemical profiles, including high levels of vitamin C and lutein. However, their dietary utilization is constrained by endogenous anti-nutritional factors (ANFs), primarily solanine and trypsin inhibitors. Using a zebrafish model, we demonstrate that these ANFs trigger intestinal dysbiosis and an oxidative-inflammatory response. Mechanistically, this adverse gut environment suppresses the mTOR pathway, as evidenced by reduced phosphorylation of S6K1 and 4E-BP1, ultimately leading to growth depression. To address this toxicological barrier, we integrated genetic selection (diploid HQP) with thermal processing (steam-cooking). Quantitative analysis revealed that while thermal processing effectively reduced ANF concentrations to physiologically safe levels, the HQP matrix retained significantly higher residual concentrations of vitamin C, lutein, and zeaxanthin compared to conventional tetraploid (C88) and wheat-based diets. Mechanistically, protein-level evidence confirmed that this processed HQP formulation promoted the total NRF2 and suppressed NF-&#954;B P65 accumulation. This metabolic shift attenuated inflammation, reactivated mTOR signaling, and subsequently enhanced growth performance and digestive capacity. Our findings establish a mechanistic framework demonstrating how integrated genomic design and processing strategies facilitate the functional utilization of high-phytochemical crops in sustainable food systems.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes - Future News 24\" \/>\n<meta property=\"og:description\" content=\"Global food security demands sustainable alternatives to the conventional feed ingredient wheat. Nutrient-dense diploid potatoes (HQP) represent candidates due to their enriched phytochemical profiles, including high levels of vitamin C and lutein. However, their dietary utilization is constrained by endogenous anti-nutritional factors (ANFs), primarily solanine and trypsin inhibitors. Using a zebrafish model, we demonstrate that these ANFs trigger intestinal dysbiosis and an oxidative-inflammatory response. Mechanistically, this adverse gut environment suppresses the mTOR pathway, as evidenced by reduced phosphorylation of S6K1 and 4E-BP1, ultimately leading to growth depression. To address this toxicological barrier, we integrated genetic selection (diploid HQP) with thermal processing (steam-cooking). Quantitative analysis revealed that while thermal processing effectively reduced ANF concentrations to physiologically safe levels, the HQP matrix retained significantly higher residual concentrations of vitamin C, lutein, and zeaxanthin compared to conventional tetraploid (C88) and wheat-based diets. Mechanistically, protein-level evidence confirmed that this processed HQP formulation promoted the total NRF2 and suppressed NF-&#954;B P65 accumulation. This metabolic shift attenuated inflammation, reactivated mTOR signaling, and subsequently enhanced growth performance and digestive capacity. Our findings establish a mechanistic framework demonstrating how integrated genomic design and processing strategies facilitate the functional utilization of high-phytochemical crops in sustainable food systems.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/\" \/>\n<meta property=\"og:site_name\" content=\"Future News 24\" \/>\n<meta property=\"article:published_time\" content=\"2026-06-23T00:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-23T04:59:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41538-026-00958-6\/MediaObjects\/41538_2026_958_Figa_HTML.png\" \/>\n<meta name=\"author\" content=\"Future News 24\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41538-026-00958-6\/MediaObjects\/41538_2026_958_Figa_HTML.png\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Future News 24\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/\"},\"author\":{\"name\":\"Future News 24\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#\\\/schema\\\/person\\\/cecad1bde21cfc357cf70128144d6c83\"},\"headline\":\"Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes\",\"datePublished\":\"2026-06-23T00:00:00+00:00\",\"dateModified\":\"2026-06-23T04:59:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/\"},\"wordCount\":226,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/media.springernature.com\\\/m685\\\/springer-static\\\/image\\\/art%3A10.1038%2Fs41538-026-00958-6\\\/MediaObjects\\\/41538_2026_958_Figa_HTML.png\",\"keywords\":[\"antinutritional\",\"constraints\",\"Design\",\"diploid\",\"efficacy\",\"enhance\",\"genomic\",\"mitigate\",\"nutritional\",\"potatoes\",\"processing\",\"Synergistic\",\"thermal\"],\"articleSection\":[\"BioTechnology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/\",\"url\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/\",\"name\":\"Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes - Future News 24\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/media.springernature.com\\\/m685\\\/springer-static\\\/image\\\/art%3A10.1038%2Fs41538-026-00958-6\\\/MediaObjects\\\/41538_2026_958_Figa_HTML.png\",\"datePublished\":\"2026-06-23T00:00:00+00:00\",\"dateModified\":\"2026-06-23T04:59:33+00:00\",\"description\":\"Global food security demands sustainable alternatives to the conventional feed ingredient wheat. Nutrient-dense diploid potatoes (HQP) represent candidates due to their enriched phytochemical profiles, including high levels of vitamin C and lutein. However, their dietary utilization is constrained by endogenous anti-nutritional factors (ANFs), primarily solanine and trypsin inhibitors. Using a zebrafish model, we demonstrate that these ANFs trigger intestinal dysbiosis and an oxidative-inflammatory response. Mechanistically, this adverse gut environment suppresses the mTOR pathway, as evidenced by reduced phosphorylation of S6K1 and 4E-BP1, ultimately leading to growth depression. To address this toxicological barrier, we integrated genetic selection (diploid HQP) with thermal processing (steam-cooking). Quantitative analysis revealed that while thermal processing effectively reduced ANF concentrations to physiologically safe levels, the HQP matrix retained significantly higher residual concentrations of vitamin C, lutein, and zeaxanthin compared to conventional tetraploid (C88) and wheat-based diets. Mechanistically, protein-level evidence confirmed that this processed HQP formulation promoted the total NRF2 and suppressed NF-&#954;B P65 accumulation. This metabolic shift attenuated inflammation, reactivated mTOR signaling, and subsequently enhanced growth performance and digestive capacity. Our findings establish a mechanistic framework demonstrating how integrated genomic design and processing strategies facilitate the functional utilization of high-phytochemical crops in sustainable food systems.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/#primaryimage\",\"url\":\"https:\\\/\\\/media.springernature.com\\\/m685\\\/springer-static\\\/image\\\/art%3A10.1038%2Fs41538-026-00958-6\\\/MediaObjects\\\/41538_2026_958_Figa_HTML.png\",\"contentUrl\":\"https:\\\/\\\/media.springernature.com\\\/m685\\\/springer-static\\\/image\\\/art%3A10.1038%2Fs41538-026-00958-6\\\/MediaObjects\\\/41538_2026_958_Figa_HTML.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/2026\\\/06\\\/23\\\/s41538-026-00958-6\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/futurenews24.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#website\",\"url\":\"https:\\\/\\\/futurenews24.com\\\/\",\"name\":\"Future News 24\",\"description\":\"The Smart Hub for AI and Next-Gen Innovation\",\"publisher\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/futurenews24.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#organization\",\"name\":\"Future News 24\",\"url\":\"https:\\\/\\\/futurenews24.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/futurenews24.com\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/fn24-favicon.png\",\"contentUrl\":\"https:\\\/\\\/futurenews24.com\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/fn24-favicon.png\",\"width\":250,\"height\":250,\"caption\":\"Future News 24\"},\"image\":{\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/futurenews24.com\\\/#\\\/schema\\\/person\\\/cecad1bde21cfc357cf70128144d6c83\",\"name\":\"Future News 24\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g\",\"caption\":\"Future News 24\"},\"sameAs\":[\"https:\\\/\\\/futurenews24.com\"],\"url\":\"https:\\\/\\\/futurenews24.com\\\/index.php\\\/author\\\/mridulpahuja20\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes - Future News 24","description":"Global food security demands sustainable alternatives to the conventional feed ingredient wheat. Nutrient-dense diploid potatoes (HQP) represent candidates due to their enriched phytochemical profiles, including high levels of vitamin C and lutein. However, their dietary utilization is constrained by endogenous anti-nutritional factors (ANFs), primarily solanine and trypsin inhibitors. Using a zebrafish model, we demonstrate that these ANFs trigger intestinal dysbiosis and an oxidative-inflammatory response. Mechanistically, this adverse gut environment suppresses the mTOR pathway, as evidenced by reduced phosphorylation of S6K1 and 4E-BP1, ultimately leading to growth depression. To address this toxicological barrier, we integrated genetic selection (diploid HQP) with thermal processing (steam-cooking). Quantitative analysis revealed that while thermal processing effectively reduced ANF concentrations to physiologically safe levels, the HQP matrix retained significantly higher residual concentrations of vitamin C, lutein, and zeaxanthin compared to conventional tetraploid (C88) and wheat-based diets. Mechanistically, protein-level evidence confirmed that this processed HQP formulation promoted the total NRF2 and suppressed NF-&#954;B P65 accumulation. This metabolic shift attenuated inflammation, reactivated mTOR signaling, and subsequently enhanced growth performance and digestive capacity. Our findings establish a mechanistic framework demonstrating how integrated genomic design and processing strategies facilitate the functional utilization of high-phytochemical crops in sustainable food systems.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/","og_locale":"en_US","og_type":"article","og_title":"Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes - Future News 24","og_description":"Global food security demands sustainable alternatives to the conventional feed ingredient wheat. Nutrient-dense diploid potatoes (HQP) represent candidates due to their enriched phytochemical profiles, including high levels of vitamin C and lutein. However, their dietary utilization is constrained by endogenous anti-nutritional factors (ANFs), primarily solanine and trypsin inhibitors. Using a zebrafish model, we demonstrate that these ANFs trigger intestinal dysbiosis and an oxidative-inflammatory response. Mechanistically, this adverse gut environment suppresses the mTOR pathway, as evidenced by reduced phosphorylation of S6K1 and 4E-BP1, ultimately leading to growth depression. To address this toxicological barrier, we integrated genetic selection (diploid HQP) with thermal processing (steam-cooking). Quantitative analysis revealed that while thermal processing effectively reduced ANF concentrations to physiologically safe levels, the HQP matrix retained significantly higher residual concentrations of vitamin C, lutein, and zeaxanthin compared to conventional tetraploid (C88) and wheat-based diets. Mechanistically, protein-level evidence confirmed that this processed HQP formulation promoted the total NRF2 and suppressed NF-&#954;B P65 accumulation. This metabolic shift attenuated inflammation, reactivated mTOR signaling, and subsequently enhanced growth performance and digestive capacity. Our findings establish a mechanistic framework demonstrating how integrated genomic design and processing strategies facilitate the functional utilization of high-phytochemical crops in sustainable food systems.","og_url":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/","og_site_name":"Future News 24","article_published_time":"2026-06-23T00:00:00+00:00","article_modified_time":"2026-06-23T04:59:33+00:00","og_image":[{"url":"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41538-026-00958-6\/MediaObjects\/41538_2026_958_Figa_HTML.png","type":"","width":"","height":""}],"author":"Future News 24","twitter_card":"summary_large_image","twitter_image":"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41538-026-00958-6\/MediaObjects\/41538_2026_958_Figa_HTML.png","twitter_misc":{"Written by":"Future News 24","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/#article","isPartOf":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/"},"author":{"name":"Future News 24","@id":"https:\/\/futurenews24.com\/#\/schema\/person\/cecad1bde21cfc357cf70128144d6c83"},"headline":"Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes","datePublished":"2026-06-23T00:00:00+00:00","dateModified":"2026-06-23T04:59:33+00:00","mainEntityOfPage":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/"},"wordCount":226,"commentCount":0,"publisher":{"@id":"https:\/\/futurenews24.com\/#organization"},"image":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/#primaryimage"},"thumbnailUrl":"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41538-026-00958-6\/MediaObjects\/41538_2026_958_Figa_HTML.png","keywords":["antinutritional","constraints","Design","diploid","efficacy","enhance","genomic","mitigate","nutritional","potatoes","processing","Synergistic","thermal"],"articleSection":["BioTechnology"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/","url":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/","name":"Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes - Future News 24","isPartOf":{"@id":"https:\/\/futurenews24.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/#primaryimage"},"image":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/#primaryimage"},"thumbnailUrl":"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41538-026-00958-6\/MediaObjects\/41538_2026_958_Figa_HTML.png","datePublished":"2026-06-23T00:00:00+00:00","dateModified":"2026-06-23T04:59:33+00:00","description":"Global food security demands sustainable alternatives to the conventional feed ingredient wheat. Nutrient-dense diploid potatoes (HQP) represent candidates due to their enriched phytochemical profiles, including high levels of vitamin C and lutein. However, their dietary utilization is constrained by endogenous anti-nutritional factors (ANFs), primarily solanine and trypsin inhibitors. Using a zebrafish model, we demonstrate that these ANFs trigger intestinal dysbiosis and an oxidative-inflammatory response. Mechanistically, this adverse gut environment suppresses the mTOR pathway, as evidenced by reduced phosphorylation of S6K1 and 4E-BP1, ultimately leading to growth depression. To address this toxicological barrier, we integrated genetic selection (diploid HQP) with thermal processing (steam-cooking). Quantitative analysis revealed that while thermal processing effectively reduced ANF concentrations to physiologically safe levels, the HQP matrix retained significantly higher residual concentrations of vitamin C, lutein, and zeaxanthin compared to conventional tetraploid (C88) and wheat-based diets. Mechanistically, protein-level evidence confirmed that this processed HQP formulation promoted the total NRF2 and suppressed NF-&#954;B P65 accumulation. This metabolic shift attenuated inflammation, reactivated mTOR signaling, and subsequently enhanced growth performance and digestive capacity. Our findings establish a mechanistic framework demonstrating how integrated genomic design and processing strategies facilitate the functional utilization of high-phytochemical crops in sustainable food systems.","breadcrumb":{"@id":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/#primaryimage","url":"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41538-026-00958-6\/MediaObjects\/41538_2026_958_Figa_HTML.png","contentUrl":"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41538-026-00958-6\/MediaObjects\/41538_2026_958_Figa_HTML.png"},{"@type":"BreadcrumbList","@id":"https:\/\/futurenews24.com\/index.php\/2026\/06\/23\/s41538-026-00958-6\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/futurenews24.com\/"},{"@type":"ListItem","position":2,"name":"Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to boost the dietary efficacy of diploid potatoes"}]},{"@type":"WebSite","@id":"https:\/\/futurenews24.com\/#website","url":"https:\/\/futurenews24.com\/","name":"Future News 24","description":"The Smart Hub for AI and Next-Gen Innovation","publisher":{"@id":"https:\/\/futurenews24.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/futurenews24.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/futurenews24.com\/#organization","name":"Future News 24","url":"https:\/\/futurenews24.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/futurenews24.com\/#\/schema\/logo\/image\/","url":"https:\/\/futurenews24.com\/wp-content\/uploads\/2026\/06\/fn24-favicon.png","contentUrl":"https:\/\/futurenews24.com\/wp-content\/uploads\/2026\/06\/fn24-favicon.png","width":250,"height":250,"caption":"Future News 24"},"image":{"@id":"https:\/\/futurenews24.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/futurenews24.com\/#\/schema\/person\/cecad1bde21cfc357cf70128144d6c83","name":"Future News 24","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/d57f07142d73cb5503ab2446ea7bc9ef3d0a5ba378d64a6157692311e42bf097?s=96&d=mm&r=g","caption":"Future News 24"},"sameAs":["https:\/\/futurenews24.com"],"url":"https:\/\/futurenews24.com\/index.php\/author\/mridulpahuja20\/"}]}},"_links":{"self":[{"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/posts\/1362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/comments?post=1362"}],"version-history":[{"count":1,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/posts\/1362\/revisions"}],"predecessor-version":[{"id":1363,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/posts\/1362\/revisions\/1363"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/media\/1364"}],"wp:attachment":[{"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/media?parent=1362"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/categories?post=1362"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/futurenews24.com\/index.php\/wp-json\/wp\/v2\/tags?post=1362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}