\n
Herrera, F. G., Bourhis, J. & Coukos, G. Radiotherapy mixture alternatives leveraging immunity for the subsequent oncology follow. CA Most cancers J. Clin. 67, 65\u201385 (2017).<\/p>\n
PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Demaria, S., Golden, E. B. & Formenti, S. C. Function of native radiation remedy in most cancers immunotherapy. JAMA Oncol. 1, 1325\u20131332 (2015).<\/p>\n
Article\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
McLaughlin, M. et al. Inflammatory microenvironment remodelling by tumour cells after radiotherapy. Nat. Rev. Most cancers 20, 203\u2013217 (2020).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Barker, H. E., Paget, J. T., Khan, A. A. & Harrington, Ok. J. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat. Rev. Most cancers 15, 409\u2013425 (2015).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Merad, M. & Salmon, H. Most cancers: a dendritic-cell brake on antitumour immunity. Nature 523, 294\u2013295 (2015).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Chen, D. S. & Mellman, I. Oncology meets immunology: the cancer-immunity cycle. Immunity 39, 1\u201310 (2013).<\/p>\n
Article\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Tang, M. et al. Toll-like receptor 2 activation promotes tumor dendritic cell dysfunction by regulating IL-6 and IL-10 receptor signaling. Cell Rep. 13, 2851\u20132864 (2015).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Saxena, M., van der Burg, S. H., Melief, C. J. & Bhardwaj, N. Therapeutic most cancers vaccines. Nat. Rev. Most cancers 21, 360\u2013378 (2021).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Wculek, S. Ok. et al. Dendritic cells in most cancers immunology and immunotherapy. Nat. Rev. Immunol. 20, 7\u201324 (2020).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Broz, M. L. et al. Dissecting the tumor myeloid compartment reveals uncommon activating antigen-presenting cells crucial for T cell immunity. Most cancers Cell 26, 638\u2013652 (2014).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Min, Y. et al. Antigen-capturing nanoparticles enhance the abscopal impact and most cancers immunotherapy. Nat. Nanotechnol. 12, 877\u2013882 (2017).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Wang, W. et al. Systemic immune responses to irradiated tumours by way of the transport of antigens to the tumour periphery by injected flagellate micro organism. Nat. Biomed. Eng. 6, 44\u201353 (2022).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Teitz-Tennenbaum, S. et al. Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Most cancers Res. 63, 8466\u20138475 (2003).<\/p>\n
CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Choi, C. W. et al. Mixture remedy of stereotactic physique radiation remedy and immature dendritic cell vaccination for augmentation of native and systemic results. Most cancers. Res. Deal with. 51, 464\u2013473 (2019).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Baharom, F. et al. Systemic vaccination induces CD8+ T cells and remodels the tumor microenvironment. Cell. 185, 4317\u20134332.e15 (2022).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Giles, J. R. et al. CD8 T cells within the cancer-immunity cycle. Immunity 56, 2231\u20132253 (2023).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Verdijk, P. et al. Restricted quantities of dendritic cells migrate into the T cell space of lymph nodes however have excessive immune activating potential in melanoma sufferers. Clin. Most cancers Res. 15, 2531\u20132540 (2009).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Buzas, E. I. The roles of extracellular vesicles within the immune system. Nat. Rev. Immunol. 23, 236\u2013250 (2023).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Ding, X. et al. Non-discriminating engineered masking of immuno-evasive ligands on tumour-derived extracellular vesicles enhances tumour vaccination outcomes. Nat. Nanotechnol. 20, 156\u2013166 (2024).<\/p>\n
Article\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Liu, G. et al. Micro organism-derived nanovesicles improve tumour vaccination by skilled immunity. Nat. Nanotechnol. 19, 387\u2013398 (2024).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Kalluri, R. & LeBleu, V. S. The biology, perform, and biomedical purposes of exosomes. Science 367, eaau6977 (2020).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Marar, C., Starich, B. & Wirtz, D. Extracellular vesicles in immunomodulation and tumor development. Nat. Immunol. 22, 560\u2013570 (2021).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Vader, P., Mol, E. A., Pasterkamp, G. & Schiffelers, R. M. Extracellular vesicles for drug supply. Adv. Drug Deliv. Rev. 106, 148\u2013156 (2016).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Wiklander, O. P. B. et al. Antibody-displaying extracellular vesicles for focused most cancers remedy. Nat. Biomed. Eng. 8, 1453\u20131468 (2024).<\/p>\n
Yue, Y. et al. Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered micro organism. Nat. Biomed. Eng. 6, 898\u2013909 (2022).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Ruhland, M. Ok. et al. Visualizing synaptic switch of tumor antigens amongst dendritic cells. Most cancers Cell 37, 786\u2013799.e5 (2020).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Pitt, J. M. et al. Dendritic cell-derived exosomes for most cancers remedy. J. Clin. Make investments. 126, 1224\u20131232 (2016).<\/p>\n
Article\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Pitt, J. M. et al. Dendritic cell-derived exosomes as immunotherapies within the struggle towards most cancers. J. Immunol. 193, 1006\u20131011 (2014).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Mu, N. et al. Plant-derived exosome-like nanovesicles: present progress and prospects. Int. J. Nanomed. 18, 4987\u20135009 (2023).<\/p>\n
Article\u00a0
\n CAS\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Lian, M. Q. et al. Plant-derived extracellular vesicles: latest developments and present challenges on their use for biomedical purposes. J. Extracell. Vesicles 11, e12283 (2022).<\/p>\n
Article\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Wong, A. S., Che, C. M. & Leung, Ok. W. Latest advances in ginseng as most cancers therapeutics: a useful and mechanistic overview. Nat. Prod. Rep. 32, 256\u2013272 (2015).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Liu, S. et al. Structural characterization of a novel polysaccharide from Panax notoginseng residue and its immunomodulatory exercise on bone marrow dendritic cells. Int. J. Biol. Macromol. 161, 797\u2013809 (2020).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Kang, S. & Min, H. Ginseng, the \u2018immunity enhance\u2019: the consequences of panax ginseng on immune system. J. Ginseng Res. 6, 354\u2013368 (2012).<\/p>\n
Article\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Krawczyk, Ok. et al. Electrogenetic mobile insulin launch for real-time glycemic management in kind 1 diabetic mice. Science 368, 993\u20131001 (2020).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Hao, Y. et al. Promotion or inhibition of extracellular vesicle launch: rising therapeutic alternatives. J. Management. Launch 340, 136\u2013148 (2021).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Mayer, A. Intracellular membrane fusion: SNAREs solely?. Curr. Opin. Cell Biol. 11, 447\u2013452 (1999).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Bennaceur, Ok. et al. Dendritic cells dysfunction in tumour surroundings. Most cancers Lett. 272, 186\u2013196 (2008).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Feng, J. et al. Plant-derived vesicle-like nanoparticles as promising biotherapeutic instruments: current and future. Adv. Mater. 35, e2207826 (2023).<\/p>\n
Article\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Li, Q. et al. The mix of gemcitabine and ginsenoside Rh2 enhances the immune perform of dendritic cells towards pancreatic most cancers by way of the CARD9-BCL10-MALT1\/NF-\u03baB pathway. Clin Immunol. 248, 109217 (2023).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Son, Ok. J., Choi, Ok. R., Lee, S. J. & Lee, H. Immunogenic cell loss of life induced by ginsenoside Rg3: significance in dendritic cell-based anti-tumor immunotherapy. Immune Netw. 16, 75\u201384 (2016).<\/p>\n
Article\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Zhang, Y. et al. Useful regulation of ginsenosides on myeloid immunosuppressive cells within the tumor microenvironment. Integr. Most cancers Ther. 18, 1534735419886655 (2019).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Kalluri, R. The biology and performance of exosomes in most cancers. J. Clin. Make investments. 126, 1208\u20131215 (2016).<\/p>\n
Article\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Mathieu, M., Martin-Jaular, L., Lavieu, G. & Th\u00e9ry, C. Specificities of secretion and uptake of exosomes and different extracellular vesicles for cell-to-cell communication. Nat. Cell Biol. 21, 9\u201317 (2019).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Savina, A., Furl\u00e1n, M., Vida, L. M. & Colombo, M. I. Exosome launch is regulated by a calcium-dependent mechanism in K562 cells. J. Biol. Chem. 278, 20083\u201320090 (2003).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Messenger, S. W., Woo, S. S., Solar, Z. & Martin, T. F. J. A Ca2+-stimulated exosome launch pathway in most cancers cells is regulated by Munc13-4. J. Cell Biol. 217, 2877\u20132890 (2018).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
MacNabb, B. W. et al. Dendritic cells can prime anti-tumor CD8+ T cell responses by way of main histocompatibility advanced cross-dressing. Immunity 55, 2206\u20132208 (2022).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Pittet, M. J., Di Pilato, M., Garris, C. & Mempel, T. R. Dendritic cells as shepherds of T cell immunity in most cancers. Immunity 56, 2218\u20132230 (2023).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Reis e Sousa, C. Dendritic cells in a mature age. Nat. Rev. Immunol. 6, 476\u2013483 (2006).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Moon, C. Y. et al. Dendritic cell maturation in most cancers. Nat. Rev. Most cancers 25, 225\u2013248 (2025).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Carrillo-Conde, B. et al. Mannose-functionalized \u2018pathogen-like\u2019 polyanhydride nanoparticles goal C-type lectin receptors on dendritic cells. Mol. Pharm. 8, 1877\u20131886 (2011).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Tomura, M. et al. Monitoring and quantification of dendritic cell migration and antigen trafficking between the pores and skin and lymph nodes. Sci. Rep. 4, 6030 (2014).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Moriya, T. et al. Immunogenic tumor cell loss of life promotes dendritic cell migration and inhibits tumor progress by way of enhanced T cell immunity. iScience 24, 102424 (2021).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Shand, F. H. et al. Monitoring of intertissue migration reveals the origins of tumor-infiltrating monocytes. Proc. Natl Acad. Sci. USA 111, 7771\u20137776 (2014).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0
\n PubMed Central\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Manno, M., Bongiovanni, A., Margolis, L., Bergese, P. & Arosio, P. The physico-chemical panorama of extracellular vesicles. Nat. Rev. Bioeng. 3, 68\u201382 (2025).<\/p>\n
Article\u00a0
\n CAS\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Wang, S. et al. Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment. Sci. Transl. Med. 13, eabb6981 (2021).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Qin, H. et al. Growth of a most cancers vaccine utilizing in vivo click-chemistry-mediated lively lymph node accumulation for improved immunotherapy. Adv. Mater. 33, e2006007 (2021).<\/p>\n
Article\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Li, N. et al. Potent prophylactic most cancers vaccines harnessing floor antigens shared by tumour cells and induced pluripotent stem cells. Nat. Biomed. Eng. 9, 215\u2013233 (2025).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n
Gong, N. et al. Enhancing in situ most cancers vaccines utilizing supply applied sciences. Nat. Rev. Drug Discov. 23, 607\u2013625 (2024).<\/p>\n
Article\u00a0
\n CAS\u00a0
\n PubMed\u00a0<\/p>\n
Google Scholar\u00a0\n <\/p>\n<\/div>\n
\n
Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Herrera, F. G., Bourhis, J. & Coukos, G. Radiotherapy mixture alternatives leveraging immunity for the subsequent oncology follow. CA Most cancers J. Clin. 67, 65\u201385 (2017). PubMed\u00a0 Google Scholar\u00a0 Demaria, S., Golden, E. B. & Formenti, S. C. Function of native radiation remedy in most cancers immunotherapy. JAMA Oncol. 1, 1325\u20131332 (2015). Article\u00a0 PubMed\u00a0 Google […]<\/p>\n","protected":false},"author":1,"featured_media":1163,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41565-026-02204-2\/MediaObjects\/41565_2026_2204_Fig1_HTML.png","fifu_image_alt":"","jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"jnews_override_bookmark_settings":[],"jnews_social_meta":[],"jnews_override_counter":[],"footnotes":""},"categories":[10],"tags":[1557,1559,805,1563,1562,1561,1560,1558],"class_list":["post-1161","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotechnology","tag-amplifying","tag-antigen","tag-cells","tag-dendritic","tag-entrapped","tag-intratumourally","tag-presentations","tag-tumour"],"yoast_head":"\n
Amplifying tumour antigen displays from intratumourally entrapped dendritic cells - Future News 24<\/title>\n<meta name=\"description\" content=\"Antigen presentation within solid tumours presents a significant clinical challenge for systemic immune activation. Although radiotherapy or chemotherapy can generate tumour antigens by destroying tumour cells, the insufficient number and impaired function of dendritic cells within solid tumours compromises effective antigen presentation. Here we present plant-derived nanoparticles coated with nanohydroxyapatite that promote dendritic cell activation and amplify the production of dendritic-cell-derived antigen-presenting vesicles in vivo through the modulation of intracellular immune conversion and calcium signalling. The technology, termed the intratumoural generation of immunopresentation vesicles after tumour exposure, enabled a dramatic enhancement in antigen presentation within lymph nodes and, consequently, boosted systemic immune response, exhibiting superior antitumour efficacy in multiple solid tumour models when combined with radiotherapy. This strategy of amplifying immunoreactive nanovesicle production in vivo may serve as a promising immunopotentiating platform, advancing various cancer treatments. A plant-based nanoparticle treatment that helps intratumoural immune cells release antigen-carrying vesicles triggers strong antitumour immunity, boosting radiotherapy efficacy.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/futurenews24.com\/index.php\/2026\/06\/18\/s41565-026-02204-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Amplifying tumour antigen displays from intratumourally entrapped dendritic cells - Future News 24\" \/>\n<meta property=\"og:description\" content=\"Antigen presentation within solid tumours presents a significant clinical challenge for systemic immune activation. Although radiotherapy or chemotherapy can generate tumour antigens by destroying tumour cells, the insufficient number and impaired function of dendritic cells within solid tumours compromises effective antigen presentation. Here we present plant-derived nanoparticles coated with nanohydroxyapatite that promote dendritic cell activation and amplify the production of dendritic-cell-derived antigen-presenting vesicles in vivo through the modulation of intracellular immune conversion and calcium signalling. The technology, termed the intratumoural generation of immunopresentation vesicles after tumour exposure, enabled a dramatic enhancement in antigen presentation within lymph nodes and, consequently, boosted systemic immune response, exhibiting superior antitumour efficacy in multiple solid tumour models when combined with radiotherapy. This strategy of amplifying immunoreactive nanovesicle production in vivo may serve as a promising immunopotentiating platform, advancing various cancer treatments. 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